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KMID : 1161420180210080823
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Journal of Medicinal Food
2018 Volume.21 No. 8 p.823 ~ p.831
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90-Day Oral Toxicity Assessment of Tropaeolum majus L. in Rodents and Lagomorphs
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de Oliveira Araujo Valdinei
Andreotti Carlos Eduardo Linhares
de Paula Reis Michelle
de Lima Daniely Alves
Pauli Karoline Bach
Nunes Bruna Caroline
Gomes Caroline
de Melo Germano Ricardo
Cardozo Euclides Lara Junior
Gasparotto Arquimedes Junior
Lourenco Emerson Luiz Botelho
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Abstract
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Tropaeolum majus L., popularly known as nasturtium, is a species widely used in the form of infusions and salads. In the last years, the antihypertensive, diuretic, and calcium and potassium sparing activities of T. majus preparations were shown. Moreover, no preclinical 90-day oral toxicity studies were conducted. Thus, this study evaluated the toxicity of the hydroethanolic extract obtained from T. majus (HETM) leaves in female and male mice, rats, and rabbits. Swiss mice and Wistar rats were treated with HETM (75, 375, and 750?mg/kg). The doses of rabbits (30, 150, and 300?mg/kg) were calculated by allometric extrapolation. The control groups received vehicle. The animals were orally treated, daily, for 90 days. At the end, the animals were anesthetized, and body weight gain, relative weight of liver, kidney, and spleen, and histopathological changes were evaluated. Serum hematological and biochemical parameters were also analyzed. No alterations were found in body and organ weights or in histopathological and biochemical evaluation. Hematological analyses revealed small changes in lymphocytes and neutrophil counts in rats after administration of 750?mg/kg of HETM. These results showed that 90-day use of T. majus is safe in rodents and lagomorphs.
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KEYWORD
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capuchinha, nasturtium, prolonged toxicity, Tropaeolaceae
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